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�ｿｽI�ｿｽ�ｿｽ�ｿｽW�ｿｽi�ｿｽ�ｿｽ�ｿｽﾆ績（Publication highlights) �ｿｽﾍ以会ｿｽ�ｿｽﾌ通ゑｿｽﾅゑｿｽ�ｿｽB

Publication Highlights

�ｿｽ�ｿｽ Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura, T. Proc Natl Acad Sci U S A 108:3701-3706, 2011
�ｿｽ�ｿｽ Suppression of experimental autoimmune encephalomyelitis by Ghrelin. Theil MM, Miyake S, Mizuno M, Tomi C, Croxford JL, Hosoda H, Theil J, von Hoersten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kangawa K, Yamamura T. J Immunol 183: 2859-2866, 2009
�ｿｽ�ｿｽ Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE. Klemann C, Raveney BJE, Klemann AK, Ozawa T, von Hoersten S, Shudo K, Oki S, Yamamura T. Am J Pathol 174: 2234-2245, 2009
�ｿｽ�ｿｽ NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T. Am J Pathol 173: 1714-1723, 2008
�ｿｽ�ｿｽ Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T. Proc Natl Acad Sci U S A 105: 8381-8386, 2008
�ｿｽ�ｿｽ Cutting Edge. Human Th17 cells are identified as bearing CCR2+CCR5-phenotype. Sato W, Aranami T, and Yamamura T. J Immunol 178:7525-7529, 2007
�ｿｽ�ｿｽ Direct Suppression of CNS Autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier E, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN. Nat Med 13:492-497, 2007
�ｿｽ�ｿｽ Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2 independent pathway. Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, and Yamamura T. Brain 129(Pt 8):1984-92, 2006
�ｿｽ�ｿｽ Invariant V�ｿｽ�ｿｽ19i T cells regulate autoimmune inflammation. Croxford, J.L., S. Miyake, Y-Y. Huang, M. Shimamura, and T. Yamamura. Nat Immunol 7: 987 -994, 2006
�ｿｽ�ｿｽ The involvement of V�ｿｽ�ｿｽ14 NKT cells in the pathogenesis of murine models of arthritis. Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S. Arthr Rheumat 52: 1941-1948, 2005
�ｿｽ�ｿｽ Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Satoh J-i, Nakanishi M, Koike F, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T. Neurobiol Dis 18:537-550, 2005
�ｿｽ�ｿｽ Modulation of CD1d-restrotced NKT cell responses by using N-acyl variants of �ｿｽ�ｿｽ-galactosylceramides. Yu KOA, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fujiwara N, Arias I, Miyake S, Yamamura T, Chang Y-T, Besra GS, and S.A. Porcelli. Proc Natl Acad Sci U S A 102: 3383-3388, 2005
�ｿｽ�ｿｽ More sympathy for autoimmunity with neuropeptide Y (NPY)? Bedoui S, Miyake S, Straub R, von Hoersten S, Yamamura T. Trends Immunol 25:508-512, 2004
�ｿｽ�ｿｽ The regulatory role of natural killer cells in multiple sclerosis. Takahashi K, Aranami T, Endoh M, Miyake S, Yamamura T. Brain 127: 1917-1927, 2004
�ｿｽ�ｿｽ The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. Oki S, Chiba A, Yamamura T, Miyake S. J Clin Invest 113: 1631-1640, 2004
�ｿｽ�ｿｽ Accumulation of V�ｿｽ�ｿｽ7.2J�ｿｽ�ｿｽ33 invariant T cells in autoimmune inflammatory lesions of the nervous system. Illes Zs, Shimamura M, Newcombe J, Oka N, Yamamura T. Int Immunol 16: 223-230, 2004
�ｿｽ�ｿｽ Natural killer T-cell activation by OCH, a sphingosine truncated analogue of �ｿｽ�ｿｽ-galactosylceramide, prevents collagen-induced arthritis. Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S. Arthr Rheumat 50:305-313, 2004
�ｿｽ�ｿｽ Th2 bias of CD4+ NKT cells derived form multiple sclerosis in remission. Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T. Int Immunol 15: 279-288, 2003
�ｿｽ�ｿｽ Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. Gumperz JE, Miyake S, Yamamura T, Brenner MB. J Exp Med 195: 625-636, 2002
�ｿｽ�ｿｽ A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Miyamoto K, Miyake S, Yamamura T. Nature 413:531-534, 2001
�ｿｽ�ｿｽ Natural killer type 2 (NK2) bias in remission of multiple sclerosis. Takahashi K., Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T. J Clin Invest 107:R23-R29, 2001
�ｿｽ�ｿｽ NR4A2 orchestrates pathogenic Th17 development and initiates autoimmune inflammation. Raveney BJE, Oki S, Yamamura T. PLOS ONE 8: e56595, 2013
�ｿｽ�ｿｽ Interleukin-6 receptor blockade in neuromyelitis optica patients non-responsive to anti-CD20 therapy. Ayzeberg I, Kleiter I, Schroder A, Hellwig K, Chan A, Yamamura T, Gold R. JAMA Neurol online first doi:10:1001/jamaneurol.2013.1246
�ｿｽ�ｿｽ Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T. Modern Rheumatol published online, (11 July 2012)
�ｿｽ�ｿｽ B-cell-directed therapy: which B cells should be targeted and how? http://www.ncbi.nlm.nih.gov/pubmed/22642324 Yamamura T, Miyake S. Immunotherapy 4: 455-457, 2012
�ｿｽ�ｿｽ Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S. Arthritis Rheum 64: 153-161, 2012
�ｿｽ�ｿｽ CCR2+CCR5+ T cells produce matrix metalloproteinase-p and osteopontin in the pathogenesis of multiple sclerosis. Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T J Immunol 189: 5057-5065, 2012

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